Search results

36,925 records were found.

BACKGROUND: Passive immunization with antibodies directed to Aβ decreases brain Aβ/amyloid burden and preserves memory in transgenic mouse models of Alzheimer's disease (AD). This therapeutic strategy is under intense scrutiny in clinical studies, but its application is limited by neuroinflammatory side effects (autoimmune encephalitis and vasogenic edema). METHODS: We intravenously administered the monoclonal Aβ protofibril antibody PFA1 to aged (22 month) male and female 3 × tg AD mice with intermediate or advanced AD-like neuropathologies, respectively, and measured brain and serum Aβ and CNS cytokine levels. We also examined 17 month old 3 × tg AD female mice with intermediate pathology to determine the effect of amyloid burden on responses to passive immunization. RESULTS: The 22 month old male mice immunized with PFA1 had decreas...
black and white view of 3 men and 2 women, wearing academic caps and gowns, standing and sitting together / people, buildings, and shrubs in background
Entrepreneurs need creative ideas to develop innovative new products. We interviewed 32 technology entrepreneurs to generate a grounded theory about how technology entrepreneurs use social behaviors, techniques and cognitive processes to attain, develop, refine, validate and filter (for usefulness) creative ideas for successful new products, processes or services. The results reveal a complex, cyclical and recursive multi-level social process with emphasis on active and social experimentation. Greatest ideational productivity occurs when strong social ties interactively solve problems in an environment of trust -- in particular, when 'Trusted Partners' exchange and refine ideas through a form of shared cognition. Findings will be of great interest to researchers interested in entrepreneurship, social creativity and management team dyna...
black and white view of 7 women, wearing academic caps and gowns over blouses and skirts, standing together outside / buildings and trees in background
The 6/7/1956 Case Institute of Technology commencement program was distributed at the convocation ceremony held to honor graduating students. It lists the speakers and participants in the ceremony, student awards, honorary degrees, and commissioning of military officers. The presence of a student's name in the commencement program should not be interpreted as an official verification of degree. Nor should the absence of a student's name be considered proof that a student did not graduate.
At head of title: Eugenics record office Superintendent: 1913- Harry H. Laughlin
Letter, signed by sender. Sent from The Rectory, Keston, Beckenham, Kent.
Letter, signed by sender. Sent from Cambridge.
Want to know more?If you want to know more about this cutting edge product, or schedule a demonstration on your own organisation, please feel free to contact us or read the available documentation at http://www.keep.pt/produtos/retrievo/?lang=en