Difference between heartwood and sapwood
Forest Products Laboratory (U.S.)
1919
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Weekly publication. Volume 34, numbers 1-52
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Fatty acid binding protein 5 (FABP5) delivers ligands from the cytosol directly to the nuclear receptor PPARβ/δ and thus facilitates the ligation and enhances the transcriptional activity of the receptor. We show here that expression levels of both FABP5 and PPARβ/δ are correlated with the tumorigenic potential of prostate cancer cell lines. We show further that FABP5 comprises a direct target gene for PPARβ/δ and thus the binding protein and its cognate receptor are engaged in a positive feedback loop. The observations demonstrate that, similarly to effects observed in mammary carcinomas, activation of the FABP5/PPARβ/δ pathway induces PPARβ/δ target genes involved in cell survival and growth and enhances cell proliferation and anchorage-independent growth in prostate cancer cells. Furthermore, the data show that downregulation of eit...
“Ambidexterity: Noun: 1. ambidextrous ease, skill, or facility; 2. unusual cleverness; 3.duplicity; deceitfulness.” Retrieved March 21, 2010, from Dictionary.com website: http://dictionary.reference.com/browse/ambidexterity
Despite their research and educational prowess, Academic Medical Centers are in a crisis. Public reporting of quality and patient satisfaction data, increasing costs, stiffer competition, and anticipated tightening of budgets have created new levels of urgency among medical school deans and hospital CEOs to increase the effectiveness of the clinical enterprise on multiple fronts. This study models an AMC as a loosely coupled system and examines how interdisciplinary teams—comprising administrators, physicians, and nurses—work to harmonize seemingly disparate quality improvement goals. Structural equation modeling t...
Much of the research in IT innovation diffusion has been in the study of the diffusion of common technological innovations that intersect human activity in business processes (e.g. web-based e-commerce). There has been less research into the diffusion of specialized technologies in high risk environments where the potentially highly negative but low probability consequences of adopting the technology can affect the adoption decision. Such technologies are employed by highly trained individuals whose work is enhanced and transformed by the IT use. Computer assisted surgery (CAS) exemplifies this technology diffusion arena: surgeons must exhibit a high level of trust in such technology while the risks associated with the use of the technology may be perceived as high. We surveyed individual orthopedic surgeons that have made adoption dec...
We have studied the reaction p↑p→nΔ++ at 6 GeV/c incident momentum in which the incident protons are 60% transversely polarized. The experiment used the Argonne National Laboratory Zero Gradient Synchrotron polarized beam and the 12-foot hydrogen bubble chamber. We report on about 6000 Δ++ events, with the Δ++ produced in the backward hemisphere in the c.m. system. Spin-density matrix elements as a function of momentum transfer are presented and small beam-polarization-induced effects are described.
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Acute lung injury (ALI) is a devastating condition resulting from diverse causes. Genetic studies of human populations indicate that ALI is a complex disease with substantial phenotypic variance, incomplete penetrance, and gene-environment interactions. To identify genes controlling ALI mortality, we previously investigated mean survival time (MST) differences between sensitive A/J (A) and resistant C57BL/6J (B) mice in ozone using quantitative trait locus (QTL) analysis. MST was significantly linked to QTLs (Aliq1-3) on chromosomes 11, 13, and 17, respectively. Additional QTL analyses of separate and combined backcross and F(2) populations supported linkage to Aliq1 and Aliq2, and established significance for previously suggestive QTLs on chromosomes 7 and 12 (named Aliq5 and Aliq6, respectively). Decreased MSTs of corresponding chrom...
