ZZH coupling : A probe to the origin of EWSB ?
Choudhury, Debajyoti
2003-02-17
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“Ali, entre delicadezas e graças espirituosas (…) a beleza é o caminho para o espírito.” Thomas Mann, A Morte em Veneza.
Depois da obra prima cinematográfica de Visconti, o Adagietto da Quinta Sinfonia de Gustav Mahler é provavelmente indissociável, para todos aqueles que conhecem o filme, da obra prima de Thomas Mann.
Mas gostaria complementar esta perspectiva de A Morte em Veneza com uma outra: a que dela nos deixa Benjamin Britten na sua última ópera, Death in Venice, estreada dois anos após o filme de Visconti, no Aldeburgh [dizer: “oldebara”] Festival, em Junho de 1973.
Benjamin Britten incubou durante largos anos o projecto de transportar para um palco de ópera A Morte em Veneza de Thomas Mann. Ditou o destino que as duas transmutações desta última – a cinematográfica de Luchino Visconti, e a musical de Benjamin Britten – surgiss...
Sudden cardiac death (SCD) and sudden unexplained death (SUD) in the young (1-44 years) is rare and is often caused by inherited cardiac diseases. Relatives of young SCD and SUD victims have an increased risk of carrying the inherited predisposition to develop cardiac disease. Early detection of inherited cardiac diseases in families offers opportunities to prevent SCD through treatment. Although the yield of screening, in terms of the detection of inherited diseases, has been investigated for relatives of SUD victims, studies on the cost-effectiveness of screening of relatives with the aim to prevent SCD are scarce. The purpose of this thesis was to provide information on the incidence and causes of SCD and SUD in the young (1-44 years) in the Netherlands and to estimate the proportion of inherited cardiac diseases. Furthermore, we st...
Graduation date: 2005
Integration of mortality data by cause of death is typically problematic for researchers because of the inadequacies of historical records. Two aspects of cause-of-death (or disease) data processing are discussed here: vocabulary and specificity. By developing a system of processing in which causes of death are in nested tables that are linked with a relational database program, the researcher can integrate highly specific and sensitive disease data with data that are less specific. Vocabulary variations can also be maintained by the system. The result of integrating data of differing specificity levels and vocabularies allows one to use mixed data for longitudinal analyses. The author developed the present system to allow the use of nineteenth-century British army statistical data, and an example of the application is presented.
Dissertation
Although the majority of pregnancy failures occur during the embryonic period, reports indicate
that approximately 5% of detected pregnancies are lost during the fetal period, underlining
the fact that fetal death is a substantial cause of economic loss. However, examination for fetal
development or death during pregnancy is not performed routinely in domestic animals, and
reference curves for normal fetal growth are, therefore, scarce. In this paper, the numerous possible
causes of fetal death are reviewed briefly, with emphasis on the role of placental problems
in fetal death and impaired fetal viability. In this respect, the role of placental insufficiency as
a cause of pregnancy loss in twin pregnancies in monotocous species is well known, whereas
the abnormal placental development leading to retarded fetal growth during pregnancie...
The division tracking dye, carboxyfluorescin diacetate succinimidyl ester
(CFSE) is currently the most informative labeling technique for characterizing
the division history of cells in the immune system. Gett and Hodgkin [Nat. Immunol.
1:239–244, 2000] have pioneered the quantitative analysis of CFSE data.
We confirm and extend their data analysis approach using simple mathematical
models. We employ the extended Gett and Hodgkin [Nat. Immunol. 1:239–244,
2000] method to estimate the time to first division, the fraction of cells recruited
into division, the cell cycle time, and the average death rate from CFSE data on T
cells stimulated under different concentrations of IL-2. The same data is also fitted
with a simple mathematical model that we derived by reformulating the numerical
model of Deenick et al. [J. Immunol. 170:4963–4972, 2...
With summary in Dutch
Dissertation
Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. In addition to MAPKs, cytokine signaling also results in activation of the transcription factor nuclear factor-kappaB (NF-κB). The upstream signaling events leading to MAPK and NF-κB activation in β-cells are not well known. The work presented in this thesis therefore aims at characterizing the regulation of MAPKs and NF-κB in human islets, with emphasis on the role of the MAPK activator MAP/ERK kinase kinase-1 (MEKK-1) in islet cell death. It was found that MEKK-1 was phosphorylated in re...
